3D QSAR kNN-MFA studies on 6-substituted benzimidazoles derivatives as Nonpeptide Angiotensin II Receptor Antagonists: A rational approach to antihypertensive agents
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چکیده
منابع مشابه
Predicting Alkylbenzimidazole Derivatives as Angiotensin II Receptor Antagonists: 3d Qsar by kNN-MFA Approach
Three dimensional quantitative structure-activity relationship (3D-QSAR) studies have been performed on a series of 2-alkylbenzimidazole derivatives using the kNN-MFA Approach (k-nearest neighbour molecular field analysis). The QSAR models were generated using 14 compounds. By using kNN-MFA approach, various 3D QSAR models were generated to study the effect of steric and electrostatic descripto...
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The three-dimensional quantitative structure-activity relationship (3D-QSAR) and pharmacophore identification studies on 28 substituted benzoxazinone derivatives as antiplatelet agents have been carried out. Multiple linear regression (MLR) method was applied for QSAR model development considering training and test set approaches with various feature selection methods. Stepwise (SW), simulated ...
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Recently several 1,3,4-oxadiazole derivatives were identified as potentially active antimycobacterial agents. Various 5-aryl-2-thio-1,3,4-oxadiazoles have been reported having good antimycobacterial activity against Mycobacterium tuberculosis H37Rv (ATCC 27294). In this paper we report 3D QSAR studies for the 41 molecules of 1,3,4-oxadiazoles by using k-Nearest Neighbor Molecular Field Analysis...
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Recently several 1,3,4-oxadiazole derivatives were identified as potentially active antimycobacterial agents. Various 5-aryl-2-thio-1,3,4-oxadiazoles have been reported having good antimycobacterial activity against Mycobacterium tuberculosis H37Rv (ATCC 27294). In this paper we report 3D QSAR studies for the 41 molecules of 1,3,4-oxadiazoles by using k-Nearest Neighbor Molecular Field Analysis...
متن کاملNonpeptide angiotensin II receptor antagonists.
Substantial progress has been made recently in the development of nonpeptide angiotensin II receptor antagonists, a goal that has long remained an unmet challenge. Pieter Timmermans and colleagues review the pharmacology and the course of events that led to the identification of the lead compound and clinical candidate DuP753. Nonpeptide angiotensin II receptor antagonists represent novel thera...
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ژورنال
عنوان ژورنال: Journal of Saudi Chemical Society
سال: 2013
ISSN: 1319-6103
DOI: 10.1016/j.jscs.2011.03.005